Paul, Ph.D. For the 4-T Study Group: Three-12 months Efficacy of Complex Insulin Regimens in Type 2 Diabetes Most individuals with type 2 diabetes require insulin therapy when oral antidiabetic agents provide suboptimal glycemic control, since long-term glycemic improvement reduces the dangers of both macrovascular1 and microvascular1,2 complications. However, different insulin regimens have varying effects on glycemic control, excess weight gain, and the risk of hypoglycemia.3 In the initial phase of the Treating to Target in Type 2 Diabetes study, we evaluated patients with type 2 diabetes who had suboptimal glycemic control despite maximally tolerated doses of metformin and sulfonylurea to see if the randomized addition of a biphasic, prandial, or basal analogue insulin would result in relevant improvement in glycated hemoglobin levels throughout a 1-calendar year period clinically.4 Although the intensification of insulin therapy reduces glycated hemoglobin amounts,5 it isn’t clear which complicated best achieves the glycemic targets regimen.However when does sending the next text message become a compulsion, like having yet another pistachio nut just? And can you be totally in the moment when you’re busy reporting onto it? It’s difficult. I don’t text very much but I really do get hundreds of emails each day. Like many, I’ve a love-hate relationship with my Blackberry. And often a hate-hate relationship. But I feel I want it to keep all of the plates spinning. I could hear what my mom would have said. She was all about appreciating the moment – and the world.