The combined group concluded that desmopressin, as the oral lyophilisate, causes a marked decrease in urinary output in hydrated kids with PNE. They finish by adding that some patients may need a higher dose to get the same effect for the whole night. By Pasquale Casale, MD Related StoriesFamily background: The most essential risk factor for prostate cancerDiabetic retinopathy therapy innovations: an interview with Richard Kirk, CEO of PolyphotonixTreating insomnia through a CBT device? 2006 Mar;97:603-9. Vande Walle JG, Bogaert GA, Mattsson S, Schurmans T, Hoebeke P, Deboe V, Norgaard JP; Desmopressin Oral Lyophilisate PD/PK Study Group.G-rard Chaouat and colleagues from Inserm et Assistance Publique et Universit – Paris Sud Orsay, Hopital Antoine B-cl-re, Clamart Cedex, France , trace the development of the research of reproductive immunology to show how the current knowledge of maternal-fetal tolerance/dialogue is rolling out, and its own implications for the treatment of infertility disorders. Their research appears in a topical issue of Developments in Neuroimmune Biology on maternal-fetal interactions. In the earliest era of reproductive immunology, immunologists searched for generalized immune suppressive activity to describe why the embryo’s cells is not rejected by the mom during pregnancy. Researchers shortly realized that systemic immune suppression was not compatible with maternal capability to reject paternal stress tissues, and it became acknowledged that some type of active maternal reputation is active in being pregnant.