Cancer may also directly harm the center by releasing toxic chemical substances that damage the muscle tissue, said Dr. Alexander Lyon, a senior lecturer in cardiology at Imperial College London and a consultant cardiologist at the Royal Brompton Medical center, also in London. In the same way that the body’s skeletal muscle wastes apart with advanced cancer, possibly the heart muscle can be affected, said Lyon, who wrote an editorial accompanying this article. But there may be other explanations for telltale symptoms of cancer-related heart harm. These hormones and body chemicals might be released within the creation of tiny new blood vessels necessary for tumor growth, for instance, said Barac, the Washington, D.C., cardiac professional. Regardless, these total results show that it’s important to measure the heart health of malignancy patients, and put them on medications to safeguard their hearts from damage due to either their tumor or the procedure they receive for this, the experts said.The study was authorized by the ethics committee at each participating institution and was conducted in accordance with the Declaration of Helsinki. All patients gave written educated consent. Risk Classification and Clinical Features Patients were classified into prognostic classes based on the karyotype of the leukemic cells . Favorable risk was defined by the current presence of abnormalities in core-binding elements; very unfavorable risk, by the presence of a monosomal karyotype16; and unfavorable risk, by the current presence of complex cytogenetic abnormalities , monosomies or partial deletions of chromosome 5 or 7 , del, -5, -7), abnormalities of the long arm of chromosome 3 , t, t, or abnormalities involving the long arm of chromosome 11 17 unless the requirements for a monosomal karyotype were fulfilled.