Abstract: Biomedical research suffers from a dramatically poor translational success www.prednisolone.org . For example, in ischemic stroke, a condition with a higher medical need, over one thousand experimental drug targets were unsuccessful. Here, we adopt methods from clinical analysis for a late-stage pre-clinical meta-analysis and randomized confirmatory trial strategy. A profound body of literature suggests NOX2 to become a major therapeutic target in stroke. Systematic review and MA of all available NOX2-/y studies exposed a positive publication bias and insufficient statistical power to detect a relevant decrease in infarct size. A completely powered multi-middle pRCT rejects NOX2 as a target to improve neurofunctional outcomes or attain a translationally relevant infarct size decrease.
Related StoriesLoyola Medicine, Palos Community Medical center jointly start innovative telemedicine programBoston Children's Medical center selects Vijay G. Sankaran to receive Rising Star AwardBoston Children's and Rock Health team up to accelerate development of pediatric wellness technologiesThe study also didn’t compare the relative safety of home births against low-risk women who chosen doctor rather than midwife-led care and say this would be the subject of a future investigation. Professor Buitendijk says the study has relevance for other countries with a highly developed health infrastructure and well-educated midwives.