Tiredness and exhaustion: In the initial stages of pregnancy the mother tires quickly and would have to rest frequently. Frequently appointments to the loo: If you often feel the need to choose urination, it can be a sign of pregnancy. Sensitive breasts: Your body must equip itself to maintain the infant after delivery. So, the noticeable changes begin to occur once you conceive. The breasts may tend to swell and be more sensitive as they aid in the production of breast milk.A statistically significant correlation . Best achieved at the 200mg dose by any patient at any time point was a 46 percent reduction at week 13. The lower 200mg dose may be therapeutically effective for a few patients nonetheless, with the view to an extended dosing period particularly.6 times the upper limit of normal which appear high in comparison to other acromegaly studies. SIGF-I levels were normalised at any point in the study in two of 13 patients dosed at 400mg weekly and in a single out of 13 on the 200mg weekly dose. Four sufferers at the 400mg per week dose acquired reductions of their sIGF-I to below the minimum entry criterion of just one 1.three times the ULN suggesting therapeutic benefit in these sufferers.